- It looks for the extension of the requested resource file e.g. (.aspx, .ascx etc.).
- It looks for ISAPI extension mapped against this file extension.
- If found a mapping, then pass request to that particular ISAPI extension.
So, For example, in case of a resource Page1.aspx file, web server will forward that request to ASP.NET Engine through ISAPI extension (aspnet_isapi.dll). At high level, ASP.NET Engine is a kind of a HTTP Pipeline because HTTP request moves through a number of HttpModules and finally reaches a particular HTTP Handler as shown in following figure.
Now, by default, request for an ASP.NET page is handled by a HttpHandler called “ASP.NET Page Handler”. Also, this request passes through a number of build-in HttpModules like OutputCache, Session, WindowsAuthentication, FormsAuthentication, RoleManager etc.
Now, hopefully it will be clear that how request flows as well as role of HttpHandlers and HttpModules in ASP.NET request flow.
To test your ASP.NET knowledge, take a simple 
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